Although prenatal DNA testing is a little more involved than a standard home DNA paternity test, the process is still fairly straightforward. The accuracy levels of prenatal DNA testing are identical to standard DNA paternity testing. Prenatal DNA testing requires samples from the unborn child, the mother, and the alleged father. DNA samples from the unborn child are collected via amniocentesis or CVS. Amniocentesis is the removal of a small sample of the amniotic fluid surrounding the fetus. Amniocentesis can be performed during the 14th to 24th week of pregnancy.

Prenatal DNA testing also requires a separate physician's fee for drawing the DNA samples. DNA samples from the parents are collected via a buccal swab rubbed against the inside of the mouth. As with standard DNA paternity testing, DNA sample collection procedures may vary depending on whether you need court-admissible results. Prenatal DNA testing for court proceedings requires proof of identities and chain of custody verification by a witness.

Questions have been raised regarding the ethics of prenatal DNA testing, given that there are risks to the fetus. But there are several instances in which prenatal DNA testing is preferred. For example, in cases of artificial insemination, there may be a need to verify the sample source.In cases of rape where there is also a consensual partner, prenatal DNA testing can determine the father of the unborn child. Determining parentage may also provide financial benefit to the mother during pregnancy. Some mothers desire prenatal DNA testing because it gives them time to plan ahead, and may reduce stress during an already very stressful time. )